Levitra 20mg - without a doctor prescription

Levitra is used to treat sexual function problems such as Impotence or Erectile Dysfunction.

Description pharmaceutical form
Round, biconvex tablets, film-coated from light orange to grayish-orange, engraved by a method of embossing: one side — branded bierowski the cross on the other — designation dosage ("5", "10" or "20" respectively).

Pharmacological action
Pharmacological action — improves erectile function.

Penile erection is a hemodynamic process in which basis the relaxation of smooth muscles of cavernous bodies and the arterioles. During sexual stimulation from nerve endings of the corpus cavernosum stands out nitric oxide (NO) activates the enzyme guanylate cyclase, which leads to higher content in the cavernous bodies of cyclic guanosine monophosphate (cGMP). The result is relaxation of smooth muscles of cavernous bodies, helps to increase blood flow into the penis. The level of cGMP is regulated, on the one hand, a synthesis called guanylate cyclase, on the other hand, degradation (breakdown) of cGMP hydrolysis by PDE. The most famous PDE is the cGMP-specific PDE-5.

Inhibiting PDE-5, which is involved in the cleavage of cGMP, vardenafil enhances the local action of endogenous nitric oxide (NO) in cavernous bodies during sexual stimulation.

The increased levels of cGMP due to intubirovannam PDE-5 leads to smooth muscle relaxation in the corpus cavernosum and increased blood flow in them.

This effect determines the ability of the drug Levitra® to strengthen a natural reaction on sexual stimulation.

Vardenafil is a potent and highly selective inhibitor of PDE-5 (medium inhibitory concentration against PDE-5 — 0.7 nm). Vardenafil inhibitory activity on PDE-5 is more pronounced than on other known PDE (15 times more than PDE-6, 130 times more than for PDE-1, 300 times greater than PDE-11 and 1000 times more than PDE-2, -3, -4, -7, -8, -9, -10). Vardenafil increased cGMP in the isolated the cavernous body, resulting in relaxation of smooth muscles. Vardenafil causes a penile erection, which depends on endogenous nitric oxide and stimulates the donators of nitrogen oxide.

Welcome vardenafil at a dose of 20 mg some men called the erection (sufficient for penetration) after 15 min. a Complete response was achieved in 25 min.